Characterizing the Relationship between Steady State and Response Using Analytical Expressions for the Steady States of Mass Action Models

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Characterizing the Relationship between Steady State and Response Using Analytical Expressions for the Steady States of Mass Action Models

The steady states of cells affect their response to perturbation. Indeed, diagnostic markers for predicting the response to therapeutic perturbation are often based on steady state measurements. In spite of this, no method exists to systematically characterize the relationship between steady state and response. Mathematical models are established tools for studying cellular responses, but chara...

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ژورنال

عنوان ژورنال: PLoS Computational Biology

سال: 2013

ISSN: 1553-7358

DOI: 10.1371/journal.pcbi.1002901